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Am J Nucl Med Mol Imaging 2012;2(2):232-241.
Review Article
In vivo and ex vivo applications of gold nanoparticles for biomedical SERS imaging
Mehmet V Yigit, Zdravka Medarova
Molecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts
General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Received February 3, 2012; accepted March 10, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Surface enhanced Raman scattering (SERS) is a signal-increasing phenomenon that occurs whenever Raman scattering
on a metal surface is enhanced many orders of magnitude. Recently SERS has received considerable attention due to its
ultrasensitive multiplex imaging capability with strong photostability. It provides rich molecular information on any Raman molecule
adsorbed to rough metal surfaces. The signal enhancement is so remarkable that identification of a single molecule is possible.
SERS has become a genuine molecular imaging technique. Gold nanoparticles, encoded with Raman reporters, provide a SERS
signal and have been used as imaging probes, often referred to as SERS nanoparticles. They have been used for molecular
imaging in vivo, ex vivo and in vitro. Detection of picomolar concentrations of target molecules has been achieved by functionalizing
the nanoparticles with target recognition ligands. This review focuses on recent achievements in utilizing SERS nanoparticles for in
vivo molecular imaging. In the near future, SERS technology may allow detection of disease markers at the single cell level.
(ajnmmi1202001).
Keywords: SERS, gold nanoparticle, Raman, molecular imaging, cancer, SERS nanoparticle
Address all correspondence to:
Dr. Mehmet Yigit, Research Fellow in Radiology, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Bldg. 75, 13th St., Charlestown, MA 02129 Tel:
617-643-4889; Fax: 617-643-4865; E-mail: myigit@nmr.mgh.harvard.edu.
Dr. Zdravka Medarova, Assistant Professor of Radiology, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center
for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Bldg. 75, 13th St., Charlestown, MA 02129 Tel:
617-643-4889; Fax: 617-643-4865; E-mail: zmedarova@partners.org
Review Article
In vivo and ex vivo applications of gold nanoparticles for biomedical SERS imaging
Mehmet V Yigit, Zdravka Medarova
Molecular Imaging Laboratory, Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts
General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Received February 3, 2012; accepted March 10, 2012; Epub March 28, 2012; Published April 15, 2012
Abstract: Surface enhanced Raman scattering (SERS) is a signal-increasing phenomenon that occurs whenever Raman scattering
on a metal surface is enhanced many orders of magnitude. Recently SERS has received considerable attention due to its
ultrasensitive multiplex imaging capability with strong photostability. It provides rich molecular information on any Raman molecule
adsorbed to rough metal surfaces. The signal enhancement is so remarkable that identification of a single molecule is possible.
SERS has become a genuine molecular imaging technique. Gold nanoparticles, encoded with Raman reporters, provide a SERS
signal and have been used as imaging probes, often referred to as SERS nanoparticles. They have been used for molecular
imaging in vivo, ex vivo and in vitro. Detection of picomolar concentrations of target molecules has been achieved by functionalizing
the nanoparticles with target recognition ligands. This review focuses on recent achievements in utilizing SERS nanoparticles for in
vivo molecular imaging. In the near future, SERS technology may allow detection of disease markers at the single cell level.
(ajnmmi1202001).
Keywords: SERS, gold nanoparticle, Raman, molecular imaging, cancer, SERS nanoparticle
Address all correspondence to:
Dr. Mehmet Yigit, Research Fellow in Radiology, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center for
Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Bldg. 75, 13th St., Charlestown, MA 02129 Tel:
617-643-4889; Fax: 617-643-4865; E-mail: myigit@nmr.mgh.harvard.edu.
Dr. Zdravka Medarova, Assistant Professor of Radiology, Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A. Martinos Center
for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Bldg. 75, 13th St., Charlestown, MA 02129 Tel:
617-643-4889; Fax: 617-643-4865; E-mail: zmedarova@partners.org
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