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Am J Nucl Med Mol Imaging 2013;3(1):97-101

Invited Perspective
“Kit like” 18F labeling method for synthesis of RGD
peptide-based PET probes

Shuanglong Liu, Ryan Park, Peter S Conti, Zibo Li

Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, California
90033, USA

Received November 19, 2012; Accepted December 6, 2012; Epub January 5, 2013; Published January 15, 2013

Abstract: Positron Emission Tomography (PET) has become a popular imaging technique widely used for diagnostic
purposes. To date, much attention has been devoted to 18F-fluoride because of the characteristics of its nuclear
decay, as well as its relative ease of preparation from 18O-water. However, with a half-life of 110 minutes, swift
and efficient incorporation of 18F-fluorine into biomolecules is necessary to minimize loss of activity. Therefore, the
discovery of rapid and reliable incorporation of 18F-fluorine atoms into biomolecules would be highly beneficial, especially
if these protocols can be carried out directly in irradiated 18O-water. In the study published in the American
Journal of Nuclear Medicine and Molecular Imaging, cyclo-RGD-18F-aryltrifluoroborate conjugates were prepared
based on one-step and one-pot-two-step methods. This paper represents recent efforts on the design and development
of novel PET tracers based on the “Kit like” 18F labeling method. (ajnmmi1211004).

Keywords: Positron emission tomography (PET), 18F, RGD, integrin αvβ3, molecular imaging

Address all correspondence to:
Dr. Zibo Li
Molecular Imaging Center
Department of Radiology
University of Southern California, Los Angeles
California 90033, USA.
E-mail: ziboli@usc.edu